Alrashidi, Tareq and Harish, Poptani (2025) Evaluating the combined effect of a choline kinase inhibitor and temozolomide therapy in a mouse model of glioblastoma using 1 H MR spectroscopy and IVIM-DWI. [Data Collection]
Data Catalogue DOI: 10.17638/datacat.liverpool.ac.uk/3027
Description
This study evaluated the therapeutic efficacy of combining a choline kinase alpha (ChoKα) inhibitor, MN58b, and Temozolomide (TMZ) in a syngeneic GL261 glioblastoma (GBM) mouse model. It used MR spectroscopy (MRS) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) to assess metabolic and microstructural changes within the tumour.
| Keywords: | Glioblastoma, GBM, IVIM, MR spectroscopy, treatment response, microstructure |
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| Date Deposited: | 25 Jun 2025 11:16 |
| Last Modified: | 25 Jun 2025 11:16 |
| DOI: | 10.17638/datacat.liverpool.ac.uk/3027 |
| Geography: | UK |
| URI: | https://datacat.liverpool.ac.uk/id/eprint/3027 |
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