Cheynel, Louise 
ORCID: https://orcid.org/0000-0003-2292-4143
(2023)
The genetics of immune and infection phenotypes in wild mice, Mus musculus domesticus.
[Data Collection]
Description
Wild animals are under constant threat from a wide range of micro- and macroparasites in their environment. Animals make immune responses against parasites, and these are important in affecting the dynamics of parasite populations. Individual animals vary in their anti-parasite immune responses. Genetic polymorphism of immune-related loci contributes to inter-individual differences in immune responses, but most of what we know in this regard comes from studies of humans or laboratory animals; there are very few such studies of wild animals naturally infected with parasites. Here we have investigated the effect of Single Nucleotide Polymorphisms (SNPs) in immune-related loci (the MHC, and loci coding for cytokines and Toll-like receptors) on a wide range of immune and infection phenotypes in UK wild house mice, Mus musculus domesticus. We found strong associations between SNPs in various MHC and cytokine-coding loci on both immune measures (antibody concentration and cytokine production) and on infection phenotypes (infection with mites, worms and viruses). Our study provides a comprehensive view of how polymorphism of immune-related loci affects immune and infection phenotypes in naturally infected wild rodent populations.
| Keywords: | Dryad,immunogenetics,host parasite interaction,ecoimmunology,Mus musculus domesticus, |
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| Depositing User: | Data Catalogue Admin |
| Date Deposited: | 04 Jul 2023 09:34 |
| Last Modified: | 04 Jul 2023 09:34 |
| DOI: | 10.5061/dryad.j6q573nk9 |
| Original Record Link: | https://datadryad.org/stash/share/rWTxI3fy2YLqlRnY_aHqiEDsfpJKCHmlJtMoFKBgmi0 |
| URI: | https://datacat.liverpool.ac.uk/id/eprint/2368 |
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