Parra, Esteban J., Mazurek, Andrew, Gignoux, Christopher R., Sockell, Alexandra, Agostino, Michael, Morris, Andrew P., Petty, Lauren E., Hanis, Craig L., Cox, Nancy J., Valladares-Salgado, Adan, Below, Jennifer E. and Cruz, Miguel (2018) Data from: Admixture mapping in two Mexican samples identifies significant associations of locus ancestry with triglyceride levels in the BUD13/ZNF259/APOA5 region and fine mapping points to rs964184 as the main driver of the association signal. [Data Collection]
Description
We carried out an admixture mapping study of lipid traits in two samples from Mexico City. Native American locus ancestry was significantly associated with triglyceride levels in a broad region of chromosome 11 overlapping the BUD13, ZNF259 and APOA5 genes. In our fine-mapping analysis of this region using dense genome-wide data, rs964184 is the only marker included in the 99% credible set of SNPs, providing strong support for rs964184 as the causal variant within this region. The frequency of the allele associated with increased triglyceride concentrations (rs964184-G) is between 30-40% higher in Native American populations from Mexico than in European populations. The evidence currently available for this variant indicates that it may be exerting its effect through three potential mechanisms: 1) modification of enhancer activity, 2) regulation of the expression of several genes in cis and/or trans, or 3) modification of the methylation patterns of the promoter of the APOA5 gene.
| Keywords: | Dryad,Fine-mapping,Admixture Mapping,BUD13/ZNF259/APOA5,Lipids,Homo Sapiens,Triglycerides,rs964184, |
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| Divisions: | Faculty of Health and Life Sciences |
| Depositing User: | Data Catalogue Admin |
| Date Deposited: | 23 Nov 2022 15:26 |
| Last Modified: | 23 Nov 2022 15:26 |
| DOI: | 10.5061/dryad.7ns5c |
| Original Record Link: | https://datadryad.org/stash/share/3NPM_SZDq4g9iiUARagEzg84BOrY2bwTrA9Q3HV80TE |
| URI: | https://datacat.liverpool.ac.uk/id/eprint/1890 |
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