Data included in the paper mp-2021-00427e.R2 titled 'Drug-polymer interactions in acetaminophen / hydroxypropylmethylcellulose acetyl succinate amorphous solid dispersions revealed by multidimensional multinuclear solid-state NMR spectroscopy'

Pugliese, Andrea ORCID: https://orcid.org/0000-0001-7328-0670, Toresco, Michael, McNamara, Daniel ORCID: https://orcid.org/0000-0001-5785-2405, Iuga, Dinu ORCID: https://orcid.org/0000-0001-9315-8250, Abraham, Anuji ORCID: https://orcid.org/0000-0003-3811-7071, Tobyn, Michael ORCID: https://orcid.org/0000-0003-0856-7821, Hawarden, Lucy E ORCID: https://orcid.org/0000-0003-1718-4937 and Blanc, Frederic ORCID: https://orcid.org/0000-0001-9171-1454 (2021) Data included in the paper mp-2021-00427e.R2 titled 'Drug-polymer interactions in acetaminophen / hydroxypropylmethylcellulose acetyl succinate amorphous solid dispersions revealed by multidimensional multinuclear solid-state NMR spectroscopy'. [Data Collection]

Data Catalogue DOI: 10.17638/datacat.liverpool.ac.uk/1418

Description

1D NMR 1H, 13C, and 15N spectra are reported recorded for the samples studied in the work (paracetamol based HPMC-AS amorphous solid dispersions at different drug loading). Also 2D NMR spectra (HETCORs and 14N-1H HMQC) are reported. Finally, XPRD patterns of the sample studied are included.

Keywords:

acetaminophen (paracetamol), hydroxypropylmethylcellulose acetyl succinate (HPMC-AS), amorphous solid dispersion, solid-state NMR, NMR spectroscopy, drug−polymer interactions, multidimensional NMR, H-bond, amotphous solid dispersion stabilty

Divisions:

Faculty of Science and Engineering > School of Physical Sciences > Chemistry

Depositing User:

Andrea Pugliese

Date Deposited:

06 Aug 2021 10:01

Last Modified:

06 Aug 2021 10:22

DOI:

10.17638/datacat.liverpool.ac.uk/1418

URI:

https://datacat.liverpool.ac.uk/id/eprint/1418