Electronic Supplementary Material (ESM)	SHEET NAME	DESCRIPTION
ESM 1	1 - Angiogenic List	Curated list of known pro- and anti-angiogenic factos used to define the AngioNet input list for network inference and enrichment analyses.
ESM 2	2 - Endurance Limma	Human endurance training differential expression (limma): pre‑ vs post‑training comparisons with effect sizes (logFC), statistics (t, P), and multiple‑testing correction (FDR) for all analysed genes.
ESM 3	3 - Resistance Limma	Human resistance training differential expression (limma): pre‑ vs post‑training comparisons with effect sizes (logFC), statistics (t, P), and multiple‑testing correction (FDR) for all analysed genes.
ESM 4	4 - Human KEGG	Human KEGG pathway enrichment results for endurance and resistance exercise signatures (GSEA/over‑representation as specified), including directionality (NES or enrichment score), P values and FDR.
ESM 5	5 - ARACNE Endurance	Endurance AngioNet network inference (ARACNE): angiogenesis‑focused interaction network derived from endurance training data, including edge list / neighbourhoods, module assignments and hub‑centred gene sets.
ESM 6	6 - ARACNE Resistance	Resistance AngioNet network inference (ARACNE): angiogenesis‑focused interaction network derived from resistance training data, including edge list / neighbourhoods, module assignments and hub‑centred gene sets.
ESM 7	7 - Rat Anatomy & Function	Rat model phenotyping summary across PR, 4 Hz, 10 Hz, 40 Hz and overload (OV): microvascular remodelling indices (e.g., C:F, capillary domain area and heterogeneity), modelled tissue PO₂ / hypoxic fraction, and muscle function (fatigue index), with group and control identifiers.
ESM 8	8 - Rat qPCR	qPCR primers, and absolute qPCR measurements for VEGF, eNOS and MMP2 (also used to validate transcriptomic signal across rat angiogenic models).
ESM 9	9 - Rat Raw Intensities	Processed/normalised rat microarray intensity matrix (feature × sample) used for downstream differential expression and pathway analyses, with sample identifiers and annotations.
ESM 10	10 - Rat Limma	Rat differential expression results (limma) for each angiogenic model versus its contralateral/control condition (e.g., PR vs CT; stimulation vs stimulation contralateral; OV vs OV contralateral), including logFC, P and FDR.
ESM 11	11 - Rat KEGG	Rat KEGG pathway enrichment results per angiogenic model (from limma‑ranked genes), including enrichment directionality (NES or score), P values and FDR, FWER.
ESM 12	12 - Rat Endurance	GSEA results testing rat model gene‑rank lists against endurance‑derived AngioNet hub gene sets/modules (hub‑set NES, P, FDR, FWER), enabling cross‑species mapping of network programmes.
ESM 13	13 - Rat Resistance	GSEA results testing rat model gene‑rank lists against resistance‑derived AngioNet hub gene sets/modules (hub‑set NES, P, FDR, FWER), enabling cross‑species mapping of network programmes.