This readme file was generated on 08.08.2022 by Wern Yew Ding GENERAL INFORMATION Title of Dataset: Stratifying clinical risk in patients with atrial fibrillation and chronic kidney disease by studying how abnormalities in clot structure/function and lipoproteins contribute to thrombosis and bleeding Author/Principal Investigator Information Name: Gregory YH Lip Institution: University of Liverpool Address: William Henry Duncan Building | 6 West Derby Street | Liverpool | L7 8TX Email: gregory.lip@liverpool.ac.uk Author/Associate or Co-investigator Information Name: Wern Yew Ding Institution: University of Liverpool Address: William Henry Duncan Building | 6 West Derby Street | Liverpool | L7 8TX Email: dwyew@hotmail.com Date of data collection: 07.08.2019 to 07.12.2020 Geographic location of data collection: Liverpool, United Kingdom Information about funding sources that supported the collection of the data: Not applicable SHARING/ACCESS INFORMATION Licenses/restrictions placed on the data: None at time of submission Links to publications that cite or use the data: Not applicable at time of submission Links to other publicly accessible locations of the data: Not applicable at time of submission Links/relationships to ancillary data sets: Not applicable at time of submission Was data derived from another source? No If yes, list source(s): Not applicable Recommended citation for this dataset: DATA & FILE OVERVIEW File List: Dataset - data deposit Relationship between files, if important: Not applicable Additional related data collected that was not included in the current data package: Not applicable Are there multiple versions of the dataset? No If yes, name of file(s) that was updated: Not applicable Why was the file updated? Not applicable When was the file updated? Not applicable METHODOLOGICAL INFORMATION Description of methods used for collection/generation of data: https://www.clinicaltrials.gov/ct2/show/NCT04043026 Methods for processing the data: Export of collected data used for analysis Instrument- or software-specific information needed to interpret the data: SPSS version 27 (IBM Corp, Armonk, NY) Standards and calibration information, if appropriate: As recommended by manufacturer Environmental/experimental conditions: Standard laboratory conditions Describe any quality-assurance procedures performed on the data: Not applicable People involved with sample collection, processing, analysis and/or submission: Wern Yew Ding DATA-SPECIFIC INFORMATION FOR: Dataset - data deposit Number of variables: 129 Number of cases/rows: 56 Variable List:StudyID Group - group allocation CKDvsNoCKD - CKD=1, no CKD=0 Age_years - age in years Gender - sex AFtype - type of AF HTN - hypertension Dyslipidaemia - dyslipidaemia DM - diabetes mellitus CAD - coronary artery disease HF - heart failure MedicalConditions - list of medical conditions LMWH - low molecular weight heparin use Antiplatelet - antiplatelet use Statin - statin use Statin_details - details of statin use CurrentMedications - list of current medications AnticoagulationType - warfarin=1, noac=2 Supplement - supplementary medications use Supplement_details - details of supplementary medications use Smoking - smoking status AlcoholFrequency - frequency of alcohol intake AlcoholAmount_UnitsPerWeek - total amount of alcohol intake per week in units Dietary_status - dietary status ExerciseFrequency - frequency of exercise FamilyHistory - family history BMI_kgm2 - body mass index in kg/m2 Pulse_bpm - pulse in bpm sBP_mmHg - systolic blood pressure in mmHg dBP_mmHg - diastolic blood pressure in mmHg Hb_gL - haemoglobin level in g/L WBC_109perL - white cell count in 10^9/L Plts_109perL - platelet count in 10^9/L MCV_fL - mean corpuscular volume in fl Haematocrit - haematocrit in percentage Neutrophils_109perL - neutrophil count in 10^9/L Lymphocytes_109perL - lymphocyte count in 10^9/L Sodium_mmolperL - sodium level in mmol/L Potassium_mmolperL - potassium level in mmol/L Urea_mmolperL - urea level in mmol/L Creatinine_μmolperL - creatinine level in μmol/L eGFR_mlmin1.73m2 - estimated glomerular filtration rate in ml/min/1.73m2 Bilirubin_μmolperL - bilirubin level in μmol/L AlkalinePhosphatase_UperL - alkaline phosphatase level in U/L ALT_UperL - alanine aminotransferase level in U/L Albumin_gperL - albumin level in g/L INR - international normalised ratio CRP_mgperL - C-reactive protein level in mg/L Fibrinogen_gperL - fibrinogen level in g/L Calcium_mmolperL - calcium level in mmol/L Phosphate_mmolperL - phosphate level in mmol/L Kaolin_LagT - lag time with Kaolin reagent in seconds Kaolin_PeakAbs - peak absorbance with Kaolin reagent in units Kaolin_Tmax - time to maximum absorbance with Kaolin reagent in seconds Kaolin_Tmax50 - time to 50% peak absorbance with Kaolin reagent in seconds Kaolin_tPA_LagT - lag time with Kaolin reagent and tPA in seconds Kaolin_tPA_PeakAbs - peak absorbance with Kaolin reagent and tPA in units Kaolin_tPA_Tmax - time to maximum absorbance with Kaolin reagent and tPA in seconds Kaolin_tPA_Tmax50 - time to 50% peak absorbance with Kaolin reagent and tPA in seconds Kaolin_tPA_TLysis50 - time to 50% clot lysis with Kaolin reagent and tPA in seconds PPP_LagT - lag time with PPP reagent in seconds PPP_PeakAbs - peak absorbance with PPP reagent in units PPP_Tmax - time to maximum absorbance with PPP reagent in seconds PPP_Tmax50 - time to 50% peak absorbance with PPP reagent in seconds PPP_tPA_LagT - lag time with PPP reagent and tPA in seconds PPP_tPA_PeakAbs - peak absorbance with PPP reagent and tPA in units PPP_tPA_Tmax - time to maximum absorbance with PPP reagent and tPA in seconds PPP_tPA_Tmax50 - time to 50% peak absorbance with PPP reagent and tPA in seconds PPP_tPA_TLysis50 - time to 50% clot lysis with PPP reagent and tPA in seconds PTT_LagT - lag time with PTT reagent in seconds PTT_PeakAbs - peak absorbance with PTT reagent in units PTT_Tmax - time to maximum absorbance with PTT reagent in seconds PTT_Tmax50 - time to 50% peak absorbance with PTT reagent in seconds PTT_tPA_LagT - lag time with PTT reagent and tPA in seconds PTT_tPA_PeakAbs - peak absorbance with PTT reagent and tPA in units PTT_tPA_Tmax - time to maximum absorbance with PTT reagent and tPA in seconds PTT_tPA_Tmax50 - time to 50% peak absorbance with PTT reagent and tPA in seconds PTT_tPA_TLysis50 - time to 50% clot lysis with PTT reagent and tPA in seconds Thrombin_LagT - lag time with Thrombin reagent in seconds Thrombin_PeakAbs - peak absorbance with Thrombin reagent in units Thrombin_Tmax - time to maximum absorbance with Thrombin reagent in seconds Thrombin_Tmax50 - time to 50% peak absorbance with Thrombin reagent in seconds Thrombin_tPA_LagT - lag time with Thrombin reagent and tPA in seconds Thrombin_tPA_PeakAbs - peak absorbance with Thrombin reagent and tPA in units Thrombin_tPA_Tmax - time to maximum absorbance with Thrombin reagent and tPA in seconds Thrombin_tPA_Tmax50 - time to 50% peak absorbance with Thrombin reagent and tPA in seconds Thrombin_tPA_TLysis50 - time to 50% clot lysis with Thrombin reagent and tPA in seconds Ks_109cm2 - permeation constant in 10^-9cm2 F1_Density - density of fraction 1 in kg/L F2_Density - density of fraction 2 in kg/L F3_Density - density of fraction 3 in kg/L F4_Density - density of fraction 4 in kg/L F5_Density - density of fraction 5 in kg/L F6_Density - density of fraction 6 in kg/L F7_Density - density of fraction 7 in kg/L F8_Density - density of fraction 8 in kg/L F9_Density - density of fraction 9 in kg/L F10_Density - density of fraction 10 in kg/L F11_Density - density of fraction 11 in kg/L F12_Density - density of fraction 12 in kg/L F13_Density - density of fraction 13 in kg/L F14_Density - density of fraction 14 in kg/L F15_Density - density of fraction 15 in kg/L F16_Density - density of fraction 16 in kg/L F17_Density - density of fraction 17 in kg/L F18_Density - density of fraction 18 in kg/L F19_Density - density of fraction 19 in kg/L F20_Density - density of fraction 20 in kg/L TotalCholesterol_mmolperL - total cholesterol level in mmol/L LDL_mmolperL - total LDL level in mmol/L HDL_mmolperL - total HDL level in mmol/L NonHDL_mmolperL - total non-HDL level in mmol/L Triglycerides_mmolperL - total triglyceride level in mmol/L WP_Cholesterol_mmolperL - total cholesterol level of whole plasma in mmol/L WP_LDL_mmolperL - total LDL level of whole plasma in mmol/L WP_sdLDL_mmolperL - total sdLDL level of whole plasma in mmol/L WP_OxLDL_ngpermL_corrected - total oxidised LDL level of whole plasma in ng/mL LDL_Cholesterol_mmolperL_corrected - total cholesterol level of LDL subclass in mmol/L LDL_LDL_mmolperL_corrected - total LDL level of LDL subclass in mmol/L LDL_sLDL_mmolperL_corrected - total sdLDL level of LDL subclass in mmol/L LDL_OxLDL_ngpermL_corrected - total oxidised LDL level of LDL subclass in ng/mL lbLDL_Cholesterol_mmolperL_corrected - total cholesterol level of large buoyant LDL subclass in mmol/L lbLDL_LDL_mmolperL_corrected - total LDL level of large buoyant LDL subclass in mmol/L lbLDL_sLDL_mmolperL_corrected - total sdLDL level of large buoyant LDL subclass in mmol/L lbLDL_OxLDL_ngpermL_corrected - total oxidised LDL level of large buoyant LDL subclass in ng/mL sdLDL_Cholesterol_mmolperL_corrected - total cholesterol level of small dense LDL subclass in mmol/L sdLDL_LDL_mmolperL_corrected - total LDL level of small dense LDL subclass in mmol/L sdLDL_sLDL_mmolperL_corrected - total sdLDL level of small dense LDL subclass in mmol/L sdLDL_OxLDL_ngpermL_corrected - total oxidised LDL level of small dense LDL subclass in ng/mL Missing data codes: Not applicable Specialized formats or other abbreviations used: Not applicable