This Dodd_SARSCoV2outcomes_readme.txt file was generated on 2021-04-07 by Dr. Susanna Dodd, University of Liverpool.

GENERAL INFORMATION

1. Title of Dataset: "SARS-CoV-2 infection outcomes (FINAL).xlsx"

2. Author Information
	A. Principal Investigator Contact Information
		Name: Dr Susanna Dodd
		Institution: University of Liverpool
		Address: University of Liverpool, Liverpool, L69 3BX, UK
		Email: s.r.dodd@liv.ac.uk

	B. Associate or Co-investigator Contact Information
		Name: Dr Sarah Gorst
		Institution: University of Liverpool
		Address: University of Liverpool, Liverpool, L69 3BX, UK
		Email: sgorst@liv.ac.uk

	C. Alternate Contact Information
		Name: Professor Paula Williamson
		Institution: University of Liverpool
		Address: University of Liverpool, Liverpool, L69 3BX, UK
		Email: prw@liv.ac.uk

3. Date of data collection (single date, range, approximate date): 2020-11-24 to 2021-03-15

4. Geographic location of data collection <latitude, longiute, or city/region, State, Country, as appropriate>: Online registry 

5. Information about funding sources that supported the collection of the data: None


SHARING/ACCESS INFORMATION

1. Licenses/restrictions placed on the data: None

2. Links to publications that cite or use the data: Dodd S, Gorst S et al. A review of the Cochrane COVID-19 Study Register reveals inconsistency in the choice and measurement of SARS-CoV-2 infection outcomes in prevention trials. F1000 (submitted)

3. Links to other publicly accessible locations of the data: None

4. Links/relationships to ancillary data sets: None

5. Was data derived from another source? Yes
	A. If yes, list source(s): Cochrane COVID-19 Study Register https://covid-19.cochrane.org/

6. Recommended citation for this dataset: SARS-CoV-2 infection outcomes in prevention trials


DATA & FILE OVERVIEW

1. File List: "SARS-CoV-2 infection outcomes (FINAL).xlsx"
Extracted data on SARS-CoV-2 infection outcomes included within prevention trial registry entries downloaded from the Cochrane COVID-19 Study Register on 2020-11-24

2. Relationship between files, if important: N/A

3. Additional related data collected that was not included in the current data package: N/A

4. Are there multiple versions of the dataset? No
	A. If yes, name of file(s) that was updated: 
		i. Why was the file updated? 
		ii. When was the file updated? 


METHODOLOGICAL INFORMATION

1. Description of methods used for collection/generation of data: Study details were extracted from individual COVID-19 prevention study registry entries downloaded from Cochrane COVID-19 Study Register (https://covid-19.cochrane.org/) on 2020-11-24. For details, see publication Dodd S, Gorst S et al. A review of the Cochrane COVID-19 Study Register reveals inconsistency in the choice and measurement of SARS-CoV-2 infection outcomes in prevention trials. F1000 (submitted)

2. Methods for processing the data: The following data were extracted for each study: intervention type (e.g. drug, vaccine, behavioural), intervention (as described verbatim), setting (i.e. population of interest), SARS-CoV-2 infection outcomes (as described verbatim), SARS-CoV-2 infection outcome definition (i.e. how SARS-CoV-2 infection would be measured), whether or not the SARS-CoV-2 infection outcome was specified as being a primary or secondary outcome, and the rationale provided for SARS-CoV-2 infection outcome measurement selection. The reviewers also recorded whether the study record related to a registry entry, trial protocol or the main report. If the registry entry record provided a link to a study protocol, this protocol was also reviewed, and the relevant data extracted.
<describe how the submitted data were generated from the raw or collected data>

3. Instrument- or software-specific information needed to interpret the data: Excel
<include full name and version of software, and any necessary packages or libraries needed to run scripts>

4. Standards and calibration information, if appropriate: N/A

5. Environmental/experimental conditions: N/A

6. Describe any quality-assurance procedures performed on the data: N/A

7. People involved with sample collection, processing, analysis and/or submission: Authors on Dodd S, Gorst S et al. A review of the Cochrane COVID-19 Study Register reveals inconsistency in the choice and measurement of SARS-CoV-2 infection outcomes in prevention trials. F1000 (submitted)


DATA-SPECIFIC INFORMATION FOR: [FILENAME]

1. Number of variables: 48

2. Number of cases/rows: 199

3. Variable List: <list variable name(s), description(s), unit(s)and value labels as appropriate for each>

The Cochrane COVID-19 Study Register download for studies filtered by study type (“interventional”), study design (“parallel/crossover”), intervention assignment (“randomised”) and study aim (“prevention”) on 2020-11-24 was supplemented with the following variables:

Protocol available (Y/N)
Record type (Registry record, Protocol, Journal article)
Prevention trial (Y/N)
Intervention (verbatim text)
Intervention type
Intervention type (categorised)
Setting (population of interest))
Setting type (categorised)
COVIDoutcome_any ("None" if no SARS-CoV-2 infection outcomes in trial)

[Remaining variables repeated for each SARS-CoV-2 infection outcomes included in study registry entry]:
COVID outcome (categorised according to how SARS-CoV-2 infection would be measured)
COVID outcome (verbatim text)
COVID outcome definition (i.e. how SARS-CoV-2 infection would be measured)
Whether or not the SARS-CoV-2 infection outcome was specified as being a primary or secondary outcome
Rationale provided for SARS-CoV-2 infection outcome measurement selection

4. Missing data codes: 
None

5. Specialized formats or other abbreviations used: 
None